“When the vaccines were first introduced, the Johnson & Johnson shot did have its benefits and there wasn’t as much supply, so people needed to get whichever vaccine was available,” Sobhanie said. People who chose Johnson & Johnson’s single-dose vaccine out of convenience or people in transient populations who could not commit to a second dose may now be opting for an mRNA booster since the benefits can be delivered in just one booster shot. (The Pfizer and the Moderna vaccines were the first ever authorized using mRNA.) ![]() Those who were originally wary of the mRNA technology early on may also be ready to adopt it now, Limaye said. But now we are noticing that there are breakthrough infections which are concerning for high-risk people that can’t afford to risk getting sick,” he said.Įffectiveness may not be the only driver prompting people who were originally vaccinated with Johnson & Johnson to opt for a different booster. “One thing we have to remember is that even in the absence of boosters, we still have pretty effective Covid vaccines and they provide a lot of protection against severe infection, hospitalization and death. Mahdee Sobhanie, an infectious diseases physician at The Ohio State University Wexner Medical Center, noted that what these antibody responses mean long-term is still unclear. ![]() Antibody levels in people who originally received Johnson & Johnson’s vaccine but were given Moderna’s booster saw a 50-fold increase in antibody levels, significantly higher than a five-fold increase in those who received a Johnson & Johnson booster.ĭr. The researchers measured antibody levels of 458 volunteers who were given a different vaccine type than their initial vaccination series. A CDC study published in September found that the Moderna vaccine was most effective at protecting against hospitalization from the delta variant, at 93 percent, followed by 88 percent for Pfizer and 71 percent for Johnson & Johnson.Ī separate National Institutes of Health study published last month looked at the safety and efficacy of mixing and matching the booster shot.
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